By W.D. Rees

over the last decade loads of examine task has happened on each side of the gastroduodenal epithelial interface, with the typical target of elucidating the mechanisms of mucosal safety and the way those can be compromised in peptic ulcer sickness. a chief stimulus to such learn has been the belief that irregular acid secretion or its supply into the duodenum in over the top quantity can't totally clarify ulcer pathogenesis within the majority of sufferers. One may possibly envisage the tummy and proximal duodenum as being in a dynamic equilibrium, with competitive luminal elements, reminiscent of acid and pepsin, being counteracted by means of protecting mucosal mechanisms. till lately, the mechanisms occupied with mucosal defense have been poorly outlined whereas the body structure and pathophysiology of acid and pepsin secretion have been elucidated. The influence that gastroduodenal mucosa was once safe by means of a unmarried mechanism has finally been changed via a extra sensible view, suggesting a few protecting zones appearing in sequence. a few of these zones might act as first or moment line defences opposed to competitive components whereas sure zones may well particularly guard opposed to definite aggressors.

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Advances in Peptic Ulcer Pathogenesis by W.D. Rees

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