By George M. Rodgers

This accomplished quantity discusses the protease ADAMTS13, summarizing the present prestige of uncomplicated and scientific examine. The 9 authoritative chapters start with a old viewpoint via exploration of the biochemistry and structure-function relationships of ADAMTS13 in addition to its general functionality in hemostasis (cleavage of von Willebrand factor). rising study issues for ADAMTS13 are lined, together with its power position in angiogenesis and different points of mobilephone biology. extra issues contain laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and purchased ADAMTS13 deficiency. A bankruptcy on comparable thrombotic microangiopathic (TMA) problems examines the variations among TMAs linked to ADAMTS13 deficiency and people now not linked to ADAMTS13 deficiency. a last bankruptcy experiences the initial details on rising elements of ADAMTS13, corresponding to the prestige of recombinant ADAMTS13 items and their power utility.


Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and disorder is an important source for medical hematologists, transfusion medication physicians, and researchers attracted to hemostasis, vascular biology, biochemistry, and metalloproteases.

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ADAMTS13: Biology and Disease by George M. Rodgers

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