By Andrew Franklin
During the process the immune reaction, antigen-activated B cells produce antibodies with elevated affinity for the antigen, a method known as affinity maturation. a bunch produces antibodies with successively better affinities with repeated publicity to an identical antigen, that is the main through which so much vaccines work.
Affinity maturation depends on hypermutation, an iterative strategy of mutation at antibody-encoding genes, by way of optimistic number of B cells expressing antibodies with elevated affinity. The mechanism of hypermutation is taken into account to be one of many final nice mysteries in molecular biology. Mutation may end up in genomic instability, so how are mutations selectively brought to antibody-encoding genes in activated B cells?
A significant step forward got here in 2000 with the invention that activation-induced deaminase (AID) is actually required for hypermutation. This was once in 2002 through facts that reduction without delay edits the DNA that encodes an antibody in an activated B mobile. a lot has on account that been learnt in regards to the biochemistry and rules of reduction, however the mechanism wherein it truly is recruited particularly to antibody-encoding genes is still enigmatic. figuring out this recruitment is clinically major simply because off-target reduction task at oncogenes may end up in chromosomal translocations and tumorigenesis.
This ebook summarizes the study on reduction within the context of its primary function within the affinity maturation of B cells.
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Extra info for Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci
Activation-Induced Deaminase: On the Targeting Mechanism of AID to the Immunoglobulin Loci by Andrew Franklin